It seems, raised hemoglobin levels are predictive of severe disease development.

“the results indicated that a combination of small changes in levels of the liver enzyme alanine aminotransferase (ALT), patient-reported myalgia (aching muscles), and raised hemoglobin levels, most accurately predicted the development severe disease.”

https://www.genengnews.com/news/prototype-ai-tool-predicts-which-coronavirus-patients-are-most-likely-to-develop-severe-disease/

Coincidentally, ALT rises as hemoglobin rises ..

“Abnormal ALT started if hemoglobin >11 g/dl females or >13.5 g/dl in males”

https://www.ncbi.nlm.nih.gov/pubmed/20967274

Treatment, therefore .. phlebotomy / hemodilution.

“The patient’s general condition improved, her dependence on supplementary oxygen drastically decreased and the blood gas values improved after hemodilution”

https://www.ncbi.nlm.nih.gov/pubmed/506807

“Serial phlebotomy works to reduce blood viscosity by hemodilution, as the plasma is restored by hydration more rapidly than are the red blood cells. The study co-authors wrote that the subsequent reduction in viscosity leads to an increase in the delivery of oxygen to the body’s tissues by two physiologic mechanisms: (1) increased cardiac output and (2) reduced oxygen shunting that occurs normally between arterioles and venules. In the first mechanism, decreased viscosity reduces the flow resistance at the peripheral vessels, thus leading to greater oxygen delivery. In the second mechanism, the difference in oxygen concentration between the arterioles and venules leads to shunting, where oxygen is extracted from arterial blood to the veins. By reducing the viscosity, flow increases and the transit time to the capillaries is reduced, thereby limiting the amount of oxygen that is extracted from the arterioles. According to the authors, "an evaluation of blood viscosity by clinical means is a useful, inexpensive outpatient clinical tool,” and “the best-known mechanism for correcting [abnormal viscosity] is repeated (but not excessively frequent) phlebotomy in small amounts.”“
"SOURCE: T. Dorman, et al. Benefits of reducing whole blood viscosity for patients with angina and dementia symptoms. Alternative Therapies, (2008) 14 (4), 48-51”

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Tom

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