On Wednesday, July 16, 2008 at 8:14:19 PM UTC-6, ironj...@aol.com wrote:
> On Jul 16, 5:53 pm, ferr...@ironcity.com wrote: snip <<
> You may think in your mind you have something to .. add .. but
> evidentally .. you don't ..
> Published ahead of print on April 23, 2008
> Clin J Am Soc Nephrol 3: 1022-1027, 2008
> (c) 2008 American Society of Nephrology
> doi: 10.2215/CJN.04491007
> ---------------------------------------------------------------------------­­­­-----
>
> Clinical Nephrology
>
> Rust Urine after Intense Hand Drumming Is Caused by Extracorpuscular
> Hemolysis
> Diego Tobal*, Alicia Olascoaga, Gabriela Moreira, Melania Kurdián*,
> Fernanda Sanchez, Maria Roselló*, Walter Alallón, Francisco Gonzalez
> Martinez*, and Oscar Noboa*,
> * Centro de Nefrología, Laboratorio Clínico, Departamento de
> Fisiopatología, Hospital de Clínicas, Facultad de Medicina
> Universidad
> de la República, Montevideo, Uruguay
>
> Correspondence: Dr. Oscar Noboa, Depto de Fisiopatología Hospital de
> Clinicas, Avda Italia s/n 11609, Montevideo, Uruguay. Phone/Fax:
> 5982-4809850; E-mail: ono...@hc.edu.uy
>
> Background and objectives: During Carnival, groups of 60 drummers go
> drumming with their hands and marching for periods of 2 to 4 h. The
> objective of this study was to determine the frequency and type of
> urinary abnormalities after candombe drumming and to evaluate
> possible
> pathogenic mechanisms.
>
> Design, setting, participants, & measurements: For analysis of
> pathogenic mechanisms, a group of individuals were prospectively
> evaluated before and after candombe drumming.
>
> Methods: Candombe drummers were recruited in January 2006, 1 wk
> before
> prolonged drumming. After clinical evaluation, urine and blood
> samples
> were obtained before and immediately after drumming.
>
> Results: Forty-five healthy individuals (four women and 41 men),
> median age 31 yr (14 to 56), were evaluated. Predrumming urine and
> plasma samples were obtained for 30 individuals. Nineteen (42%) of 45
> had a previous history of rust urine emission temporally related with
> candombe drumming. After drumming, 18 of 26 showed urine
> abnormalities; six of 26 showed rust urine, eight of 26 had
> microhematuria, and seven of 26 had proteinuria >1 g/L. The candombe
> drummers who showed rust urine after heavy drumming presented
> significantly higher levels of lactate dehydrogenase and total
> bilirubin when compared with those without urine abnormalities.
> Haptoglobin was significantly lower in the rust urine group.
> Fragmented red cells were observed in the blood smear of individuals
> with rust urine. Rust urine after drumming was associated with
> previous episodes of rust urine and glucosuria.
>
> Conclusions: Taken together, these data confirm that rust urine is
> caused by extracorpuscular hemolysis.
> --------------------------------
> Med Sci Monit. 2008 Jan;14(1):CS1-4. Links
> Myoglobinuria caused by exertional rhabdomyolysis misdiagnosed as
> psychiatric illness.
> Banasik M, Ku¼niar J, Kusztal M, Porazko T, Weyde W, Klinger M.
> Department of Nephrology and Transplantation Medicine, Wroc³aw
> Medical
> University, Wroc³aw, Poland. m.bana...@interia.pl
>
> BACKGROUND:
> Rhabdomyolysis is severe and acute skeletal muscle damage resulting
> in
> sarcolemma disruption. During injury, intracellular muscle contents
> are released into the plasma. The consequences may cause hypovolemia,
> electrolyte abnormalities, compartment syndrome, or even acute renal
> failure and dialysis. CASE REPORT:
> We present the history of a patient in whom exertional rhabdomyolysis
> was misdiagnosed. A 20-year-old male police recruit was admitted to a
> psychiatric hospital because of complaints about black urine and
> severe thigh pain.
> Serum creatinine kinase (CK) was significantly elevated at 87,335 U/
> l.
> Urinalysis showed brown color and cloudiness.
> Serum myoglobin was also significantly increased.
> Aspartate aminotransferase was elevated as was alanine
> aminotransferase. Immediate intravascular fluid hydration and
> hospital
> rest under renal, metabolic, and hematological monitoring was
> performed.
> CONCLUSIONS:
> Gymnastic teachers and people at environmental risk of
> rhabdomyolysis,
> such as members of the armed forces, police, and supervisors of
> physical laborers, need to remember the risks of intensive and
> repetitive exercise.
> Symptoms such as dark urine, myalgia, and muscle weakness should
> immediately arouse suspicion of rhabdomyolysis.
> Especially dark-colored urine should always be investigated for the
> occurrence of rhabdomyolysis.
>
> PMID: 18172418 [PubMed - indexed for MEDLINE]
> -----------------------
>
> Deduction using reason .. logic .. science.
>
> Rhabdomyolysis is caused by exercise.
> Exercise causes hemolysis.
> Snake venom causes Rhabdomyolysis.
> Snake venom causes hemolysis.
> Hemolysis Causes Rust Urine
> Rhabdomyolysis Causes Rust Urine
>
> Voila ..
>
> http://members.tripod.com/~baggas/rhabdo.html
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!
> http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9f

Targeting Labile Iron-Mediated Ferroptosis Provides a Potential Therapeutic Strategy for Rhabdomyolysis-Induced Acute Kidney Injury
Haiying Zhu 1, Jie Cen 2, Chenggang Hong 1, Haiyang Wang 2, Yuanmei Wen 3, Qiaojun He 1 3 4 5, Yongping Yu 2 4, Ji Cao 1 3 4 5, Wenteng Chen 2 4
ACS Chem Biol. 2023 May 12.
PMID: 37172039 DOI: 10.1021/acschembio.2c00914
Abstract
Acute kidney injury (AKI) is a global health problem that occurs in a variety of clinical settings. Despite some advances in supportive clinical care, no medicinal intervention has been demonstrated to reliably prevent AKI thus far. Therefore, it is highly necessary to investigate the pathophysiology and mechanisms involved in AKI for the discovery of therapeutics. In the current study, a robust change in the level of renal malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) and elevated renal iron levels were observed in murine rhabdomyolysis-induced AKI (RM-AKI), which supports a pathogenic role of labile iron-mediated ferroptosis and provides a chance to utilize iron chelation for RM-AKI prevention. Given that the existing small molecule-based iron chelators did not show promising preventative effects against RM-AKI, we further designed and synthesized a new hydroxypyridinone-based iron chelator to potently inhibit labile iron-mediated ferroptosis. Lead compound AKI-02 was identified, which remarkably protected renal proximal tubular epithelial cells from ferroptosis as well as showed excellent iron chelation ability. Moreover, administration of AKI-02 led to renal function recovery, a result that was substantiated by the decreased contents of BUN and creatinine, as well as the reduced labile iron level and improved histopathology. Thus, our studies highlighted that targeting labile iron-mediated ferroptosis could provide therapeutic benefits against RM-AKI.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk