Rocksolid Light

News from da outaworlds

mail  files  register  groups  login

Message-ID:  

You will step on the night soil of many countries.

sci / sci.med.nutrition / Iron In Hemolysis

SubjectAuthor
* Iron In Hemolysisironjustice
`- Re: Iron In Hemolysisironjustice

1
Subject: Iron In Hemolysis
From: ironjustice
Newsgroups: sci.med.nutrition
Date: Fri, 27 Aug 2021 12:37 UTC
X-Received: by 2002:a37:96c2:: with SMTP id y185mr8947844qkd.6.1630067850744; Fri, 27 Aug 2021 05:37:30 -0700 (PDT)
X-Received: by 2002:aca:6109:: with SMTP id v9mr6493808oib.147.1630067850381; Fri, 27 Aug 2021 05:37:30 -0700 (PDT)
Path: eternal-september.org!news.eternal-september.org!reader01.eternal-september.org!reader02.eternal-september.org!news.uzoreto.com!tr1.eu1.usenetexpress.com!feeder.usenetexpress.com!tr1.iad1.usenetexpress.com!border1.nntp.dca1.giganews.com!nntp.giganews.com!news-out.google.com!nntp.google.com!postnews.google.com!google-groups.googlegroups.com!not-for-mail
Newsgroups: sci.med.nutrition
Date: Fri, 27 Aug 2021 05:37:30 -0700 (PDT)
Injection-Info: google-groups.googlegroups.com; posting-host=2001:56a:723e:aa00:f92f:652:d822:4e5c; posting-account=hBAG4AoAAABOaauYJdMbCKnI-qYy_97e
NNTP-Posting-Host: 2001:56a:723e:aa00:f92f:652:d822:4e5c
User-Agent: G2/1.0
MIME-Version: 1.0
Message-ID: <039bf813-72e3-4118-905c-512ce8eef980n@googlegroups.com>
Subject: Iron In Hemolysis
From: teamtanner@hotmail.com (ironjustice)
Injection-Date: Fri, 27 Aug 2021 12:37:30 +0000
Content-Type: text/plain; charset="UTF-8"
Content-Transfer-Encoding: quoted-printable
Lines: 42
View all headers

Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
Eri Manabe 1, Satoyasu Ito 2, Yoshiya Ohno 3, Toshiyuki Tanaka 3, Yoshiro Naito 4, Naoko Sasaki 2, Masanori Asakura 4, Tohru Masuyama 4 5, Masaharu Ishihara 4, Takeshi Tsujino 4 2
Affiliations expand
PMID: 33328561 PMCID: PMC7744793 DOI: 10.1038/s41598-020-79146-9
Free PMC article
Abstract
We studied the mechanisms of anemia and the influence of anemia on renal pathology in Dahl/Salt Sensitive (Dahl/SS) rat, a model of cardio-renal-anemia syndrome. Erythrocyte lifespan was shortened and associated with decreased hemoglobin level in the Dahl/SS rats given high-salt diet. Serum haptoglobin decreased, reticulocytes increased, and erythropoiesis in the bone marrow and extramedullary hematopoiesis in the spleen was markedly stimulated by increased serum erythropoietin in them. As a mechanism of hemolysis, we investigated the incidence of eryptosis, suicidal death of erythrocytes. Eryptosis was increased, and red blood cell-derived microparticles, small particle which are generated in hemolytic disease, were also increased in Dahl/SS rats fed with high-salt diet. Deposition of hemosiderin and mitochondrial morphologic abnormality, a sign of ferroptosis, in proximal renal tubules was associated with intravascular hemolysis. Treatment with deferasirox, an oral iron chelator, reduced the renal proximal tubular injury and the glomerular sclerosis in Dahl/SS rats fed with high-salt diet. In conclusion, reduced half-life of erythrocytes induced by hemolysis is the major cause of anemia in Dahl/SS rat. Iron accumulation induced by hemolysis causes renal proximal tubule injury and accelerates renal damage in this model.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Subject: Re: Iron In Hemolysis
From: ironjustice
Newsgroups: sci.med.nutrition
Date: Sat, 28 Aug 2021 06:17 UTC
References: 1
X-Received: by 2002:a0c:e042:: with SMTP id y2mr13719045qvk.21.1630131445604;
Fri, 27 Aug 2021 23:17:25 -0700 (PDT)
X-Received: by 2002:a9d:20a2:: with SMTP id x31mr11264406ota.346.1630131445288;
Fri, 27 Aug 2021 23:17:25 -0700 (PDT)
Path: eternal-september.org!news.eternal-september.org!reader01.eternal-september.org!reader02.eternal-september.org!news.mixmin.net!proxad.net!feeder1-2.proxad.net!209.85.160.216.MISMATCH!news-out.google.com!nntp.google.com!postnews.google.com!google-groups.googlegroups.com!not-for-mail
Newsgroups: sci.med.nutrition
Date: Fri, 27 Aug 2021 23:17:25 -0700 (PDT)
In-Reply-To: <039bf813-72e3-4118-905c-512ce8eef980n@googlegroups.com>
Injection-Info: google-groups.googlegroups.com; posting-host=2001:56a:723e:aa00:f92f:652:d822:4e5c;
posting-account=hBAG4AoAAABOaauYJdMbCKnI-qYy_97e
NNTP-Posting-Host: 2001:56a:723e:aa00:f92f:652:d822:4e5c
References: <039bf813-72e3-4118-905c-512ce8eef980n@googlegroups.com>
User-Agent: G2/1.0
MIME-Version: 1.0
Message-ID: <2fbb5da5-514c-404c-a7cf-1a3544ee9c81n@googlegroups.com>
Subject: Re: Iron In Hemolysis
From: teamtanner@hotmail.com (ironjustice)
Injection-Date: Sat, 28 Aug 2021 06:17:25 +0000
Content-Type: text/plain; charset="UTF-8"
Content-Transfer-Encoding: quoted-printable
View all headers

On Friday, August 27, 2021 at 6:37:31 AM UTC-6, ironjustice wrote:
> Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage
> Eri Manabe 1, Satoyasu Ito 2, Yoshiya Ohno 3, Toshiyuki Tanaka 3, Yoshiro Naito 4, Naoko Sasaki 2, Masanori Asakura 4, Tohru Masuyama 4 5, Masaharu Ishihara 4, Takeshi Tsujino 4 2
> Affiliations expand
> PMID: 33328561 PMCID: PMC7744793 DOI: 10.1038/s41598-020-79146-9
> Free PMC article
> Abstract
> We studied the mechanisms of anemia and the influence of anemia on renal pathology in Dahl/Salt Sensitive (Dahl/SS) rat, a model of cardio-renal-anemia syndrome. Erythrocyte lifespan was shortened and associated with decreased hemoglobin level in the Dahl/SS rats given high-salt diet. Serum haptoglobin decreased, reticulocytes increased, and erythropoiesis in the bone marrow and extramedullary hematopoiesis in the spleen was markedly stimulated by increased serum erythropoietin in them. As a mechanism of hemolysis, we investigated the incidence of eryptosis, suicidal death of erythrocytes. Eryptosis was increased, and red blood cell-derived microparticles, small particle which are generated in hemolytic disease, were also increased in Dahl/SS rats fed with high-salt diet. Deposition of hemosiderin and mitochondrial morphologic abnormality, a sign of ferroptosis, in proximal renal tubules was associated with intravascular hemolysis. Treatment with deferasirox, an oral iron chelator, reduced the renal proximal tubular injury and the glomerular sclerosis in Dahl/SS rats fed with high-salt diet. In conclusion, reduced half-life of erythrocytes induced by hemolysis is the major cause of anemia in Dahl/SS rat. Iron accumulation induced by hemolysis causes renal proximal tubule injury and accelerates renal damage in this model.
>
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
>
> Man Is A Herbivore!
> http://tinyurl.com/4rq595
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

“Iron accumulation is associated with the pathogenesis of several cardiovascular diseases. However, the preventive effects of iron restriction (IR) against cardiovascular disease remain obscure. We investigated the effects of dietary IR on cardiovascular pathophysiology and the involved mechanism in Dahl salt-sensitive rats.”
“IR could be an effective strategy for prevention of HS-induced organ damage in salt-sensitive hypertensive patients.”

https://pubmed.ncbi.nlm.nih.gov/21263124/

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

1

rocksolid light 0.9.8
clearnet tor