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sci / sci.life-extension / Re: Iron In Shortened Telemores

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* Iron In Shortened Telemoresironjustice
`- Re: Iron In Shortened Telemoressciw...@gmail.com

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Subject: Iron In Shortened Telemores
From: ironjustice
Newsgroups: sci.life-extension
Date: Fri, 23 Oct 2020 18:02 UTC
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Subject: Iron In Shortened Telemores
From: teamtanner@hotmail.com (ironjustice)
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LEUKOCYTE TELOMERE LENGTH IS ASSOCIATED WITH IRON OVERLOAD IN MALE ADULTS WITH HEREDITARY HEMOCHROMATOSIS
Biosci Rep
2020 Oct 7;BSR20201916. doi: 10.1042/BSR20201916.
Maximiliano Martin 1, Andrea Millan 2, Florencia Ferraro 1, Walter Francisco Tetzlaff 3, Ezequiel Lozano Chiappe 1, Eliana Botta 1, Marcelo Castro 4, Laura Boero 1, Jorge Rey 4, Jorge Daruich 4, Gustavo Frechtel 2, Tomas Merono 3, Gloria Cerrone 2, Fernando Brites 1
PMID: 33026063 DOI: 10.1042/BSR20201916
Free article
Abstract
Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.
Aim: To evaluate the relationship between ATL and IO in patients with HH.
Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls.
Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.
Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05).
Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.

Keywords: Iron Metabolism; Iron Overload; Telomere Lenght.

Copyright 2020 The Author(s).

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Subject: Re: Iron In Shortened Telemores
From: sciw...@gmail.com
Newsgroups: sci.life-extension
Date: Mon, 21 Dec 2020 22:13 UTC
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Subject: Re: Iron In Shortened Telemores
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On Saturday, October 24, 2020 at 7:02:39 AM UTC+13, ironjustice wrote:
> LEUKOCYTE TELOMERE LENGTH IS ASSOCIATED WITH IRON OVERLOAD IN MALE ADULTS WITH HEREDITARY HEMOCHROMATOSIS
> Biosci Rep
> 2020 Oct 7;BSR20201916. doi: 10.1042/BSR20201916.
> Maximiliano Martin 1, Andrea Millan 2, Florencia Ferraro 1, Walter Francisco Tetzlaff 3, Ezequiel Lozano Chiappe 1, Eliana Botta 1, Marcelo Castro 4, Laura Boero 1, Jorge Rey 4, Jorge Daruich 4, Gustavo Frechtel 2, Tomas Merono 3, Gloria Cerrone 2, Fernando Brites 1
> PMID: 33026063 DOI: 10.1042/BSR20201916
> Free article
> Abstract
> Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition.. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.
> Aim: To evaluate the relationship between ATL and IO in patients with HH.
> Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls.
> Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.
> Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05).
> Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.
>
> Keywords: Iron Metabolism; Iron Overload; Telomere Lenght.
>
> Copyright 2020 The Author(s).
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http://tinyurl.com/2r2nkh
>
>
> Man Is A Herbivore!
> http://tinyurl.com/a3cc3
>
>
> DEAD PEOPLE WALKING
> http://tinyurl.com/zk9fk

And yet he fed many with loaves of bread and fish, if I remember rightly.
You'd be hard pressed nowadays to find a piece of fish that wasn't contaminated with Mercury
or dioxin or some other pathogen. Similarly most breads contain toxins.

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