Does anyone have conclusive knowledge on this topic ?

The NIH, USA, researched this and haven't reached any definite
results.
This involved the investigation of the regulatory pathways; most
likely utilizing computational methods and further biological trials.

Folding at home have produced the 3D structure of the p53 molecule,
bringing regulation of this, or by this, molecule close to reality.

On Thursday, July 9, 2020 at 12:24:37 PM UTC+12, Edward Montague wrote:
> Does anyone have conclusive knowledge on this topic ?
>
> The NIH, USA, researched this and haven't reached any definite
> results.
> This involved the investigation of the regulatory pathways; most
> likely utilizing computational methods and further biological trials.
>
> Folding at home have produced the 3D structure of the p53 molecule,
> bringing regulation of this, or by this, molecule close to reality.

More details;

https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-0705-7

On Thursday, July 9, 2020 at 12:24:37 PM UTC+12, Edward Montague wrote:
> Does anyone have conclusive knowledge on this topic ?
>
> The NIH, USA, researched this and haven't reached any definite
> results.
> This involved the investigation of the regulatory pathways; most
> likely utilizing computational methods and further biological trials.
>
> Folding at home have produced the 3D structure of the p53 molecule,
> bringing regulation of this, or by this, molecule close to reality.

https://www.nature.com/scitable/content/the-p53-and-rb-tumour-suppressor-pathways-14267125/

https://foldingathome.org/diseases/cancer/p53/

https://mcr.aacrjournals.org/content/9/11/1493

https://en.wikipedia.org/wiki/P53

Can't locate the original image at folding@home, probably there ; somewhere.

It's winter here , negative temperatures, the windows have been closed; I feel somewhat groggy. Open a window this afternoon, may eventually feel better.

The Nature website does appear to contain a considerable amount of information; even if there doesn't appear to be any unifying
structure. Perhaps the inclusion of code will go someway towards addressing that issue.

What I see is a diverse range of methodologies, providing information at a higher level than raw data, and yet lacking the
ability to bring this diverse information together.

For life extension we require the presentation of biological pathways and associated information in a format that's easy to
comprehend. Just now I'm imagining a large screen with a certain
pathway illustrated, a simulation is running and select portions
of the pathway are illuminated to a greater extent than all others; on another panel three dimensional models of the relevant molecular interactions are shown at a high frame rate
using ray, path or other tracing methods.

Artificial Intelligence, most likely will drive this, however
somewhat knowledgeable humans are there also.

Life extension and the mitigation of disease are a balancing
act, the mathematics that might describe this aren't apparent.
Biological pathways hint at what this might be, yet remain
beyond the comprehension of many.

On Thursday, July 9, 2020 at 12:24:37 PM UTC+12, Edward Montague wrote:
> Does anyone have conclusive knowledge on this topic ?
>
> The NIH, USA, researched this and haven't reached any definite
> results.
> This involved the investigation of the regulatory pathways; most
> likely utilizing computational methods and further biological trials.
>
> Folding at home have produced the 3D structure of the p53 molecule,
> bringing regulation of this, or by this, molecule close to reality.

The Sanger Institute has a few ongoing projects,
including the genome of various cancers.
In some instances multiple genes are affected,
sometimes the very structure of the genome is
altered.
The cell usually has multiple ways of correcting this.

The number of genes corrupted thus far, appear to be
finite.
The genomic changes in structure may require a different approach than expected.