Noting that a drug carrying microsome or liposome could have three layers, one of them surgical glue, a pill that has as outer layer that only dissolves when the microsome or liposome is at direct contact with a GI tract membrane, then enzymatically degraded right at the membrane surface that exterior layer dissolves exposing the surgical glue layer, the surgical glue then glues the drug diffusing core to the membrane and the glued-on drug diffuses to the system as long as the surgical glue holds, palmitate drugs like fluoxetine palmitate last 7 days on ingestion so if the surgical glue lasts a month then 37 day oral pill is produced, at the brush cytes of the GI tract membrane an acetylase is produced that divides sucrose at the acetyl to make glucose and fructose, an acetylated polymer that disintegrates at the membrane, when next to brush cytes could be produced, one particularly affordable possibility is a sucrose polymer

An oral pill that lasts a year, at a three layer pill, an endocytosis moiety or protein that effects vascular epithelia to do endocytosis, at a location physically just after the membrane, is attached to the drug, the vascular cytes uptake the drug then it gradually diffuses out of their cytoplasm into the circulatory system, at a better version it is possible that enzymatically degradable ensconcement proteins of 1-14 different thickness layers are around the actual drug that endocytosis has brought to the cytoplasm of the vascular cytes, between each of the 14 layers of ensconscement protein is some active drug, and so as cytoplasmic enzymes gradually wear away the layers of the ensconcement protein 14 gradually diffusing doses are activated, the actual drug molecule could have an efflux transport channel moiety or peptide on it so the vascular cyte would actively place the drug at the circulatory system, drugs that are active at microgram or nanogram quantities per 24 hours support this, peptide drugs, protein drugs, antigens where repeated multiday exposure builds greater immunoresponse (say to malaria or mTOR receptors), as well as ethynyl fluorinated drugs with cytomembrane transport channel moieties on them (1000 times activity from halogenation, 1000 ethynylization, 1000 cytotransport moiety) these drugs can be potent at a millionth the starting drug molecule's dose, a 700 nanogram/24 hour dose is just 256 micrograms of drug at the oral pill, a 300 microgram a day dose is just 1.1 mg of drug at the pill, a once a year oral contraceptive would be beneficial and has less than 1mg of active pharmaceutical ingredient

A longevity drug pill you take once a year, or once every few centuries is beneficial

People thought about to be other than alive could get gene therapy that provides benefit across the full range of things they think could happen if a person ceases to be alive, from making people nicer and more intelligent, to having the genetics of people who are absent any aversive sensation to any aversive stimulus, including asphyxia, to having the genetics of the mentally well, Tolerance of crowding, as well as the genetics of being calm, as an effective gene therapy this could be oral gene therapy or injected, and it is also beneficial to inject in the bodies of the previously alive