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sci / sci.engr / Complex personality prediction, MWI technology, longevity

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o Complex personality prediction, MWI technology, longevityKay Lie

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Subject: Complex personality prediction, MWI technology, longevity
From: Kay Lie
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Date: Wed, 26 Jul 2023 11:38 UTC
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Subject: Complex personality prediction, MWI technology, longevity
From: liekay631@gmail.com (Kay Lie)
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Longevity technology

what works on everything? plants, yeast, people?

is there anything about being a perennial plant, as compared to an annual plant that could have a genetic coevolution at humans, like vasular plants of a certain kind of vascularity are perennials, and multicentruy lifespan ones have a particular kind of vasculature.

are any ion transport channels conserved between plants and people. I read about 1/5 of genes are actually the same, so the entire suite of “most optimal at plants” at that 20% could be compared withthe human version, then those 20% of shared genes could be optimized based on the most longevity and capability beneficial plant versions of those genes; also there is the engineering approach as well. Like, say, plants use only 1/3 as much ATP to transfer a glucose across a cytomembrane, just going for the plant genes might not function, but the way the better transport channel actually physicochemically works, and computer simulations of the proteins itismade outof could provide a place for humans to create a new gene based on the physical chemistry of the transport channel.

Molecular biology generalizables, repeatable forms, and things (feeling unclueful, but like: things) such as a alpha helices, twisty ladders, beta sheets, barrels, and things that look kind of like like notebookpaper iris flourishes are, as likely almost any genetic engineer knows, tunable (9% longer, 3% more curve), adjustable (twice as tall), taxonomically findable (5000 different beta sheets and where to find them, and the nucleic acid sequences that make them, and the ribosomes/ER/golgi structure that build them) at a lookup catalog for any particular organism; so like, find the 20% of genes shared with plants, see what has better engineering, then use the databases (catalogs)

So, there is a way to make things at a cyte I just read about, “n contrast, non-proteinogenic amino acids are amino acids that are either not incorporated into proteins (like GABA, L-DOPA, or triiodothyronine), misincorporated in place of a genetically encoded amino acid, or not produced directly and in isolation by standard cellular machinery (like hydroxyproline).. The latter often results from post-translational modification of proteins.. Some non-proteinogenic amino acids are incorporated into nonribosomal peptides which are synthesized by non-ribosomal peptide synthetases.” So as a longevity technology there are a whole bunch of cytochemicals and cytoproteins called nonproteinogenic amino acids that are not make by the ribosome, and some of them might have longevity, wellness, healthspan and youthful phenotype effects; is there a way to cause these nonproteogenic amino acids to be at teenage amounts, locations, and production as a response to various body and cyto triggers? The cytomechanisms that do that teenage amountness, or most strongly support the production of, or are like the rate-limiting step at, the production of nonproteinogenic amino acids could be longevity drug mechanisms.

Also, noting these are nonproteinogenic, it is possible that their production is vaugely associated with amounts of enzymes and substrates floating around in the cytoplasm, as compared with frequency of transcription of a codon sequence at a nucleus and a ribosome, so that suggests that as compared with a genetic source, nonproteogenic amino acids have a much more fluid, completely computationally different dynamic and modellable sourcing and residable areas; So, they could look at the nonproteogenic math models that describe actual chemicals at supercentanarians and prepubertal children and find out if they are like 7% different of 300% different, and then come up with approaches to bring the supercentanarian nonproteinogenic chemistry to be like that of the prepubertal children, This could be based on endogenous production of more, less, or molecularly different nonproteinogenic amino acids; making the repairs or improvements durable, gene therapy or gene optimization at the germline could be used to affect the nonproteinogenic amino acids. This could possibly be based on the gene based production of things like enzymes and prechemicals (substrates) at, or with, the genes that code ribosome-made proteinogenic amino acid sequences to make things like enzymes. Compared with gene therapy to make more things like enzymes and substrates, as a longevity technology supplements, probiotic secretions, or possibly at some things, depot injections could make the supercentenarians and anyone older than a prepubertal child’s quantitative measurements to be those of a prepubertal child.

As a longevity drug source, I think a computer program could just screen the multiply interconnected: [protein and chemical and protein effect each other] network diagrams I have seen, then make a list of the ones with the largest variability, the largest mass of actual chemicals produced, the particular rate limiting step chemicals and the biggest differences between chemical amounts at supercentenarians and prepubertal children, and then from those lists make a new list of differenter, bigger, most and least supply assurability, and possibly if any of them are essential to like 2 or 11 different simulataneous mostly unrelated processes, making them kind of like having effect multipliers. So then you get a list of nongenetic nonproteinforming amino acids where anomolies are possibly repairable with supplementation (or gene therapy on things like enzymes, or enzyme substrate production) and the repair of those anomolies can be quantitatively measured as to if they have a longevity, wellness, healthspan, as well as phenotypic youthfulness of the organism, such as a human effect.

Also, finding the rate limiting step, when either a nonproteinforming amino acid is either being produced, or when a nonproteinforming amino acid is the actual rate limiting step of another cytological or tissue or body activity, finds things where more or less of it could have a wellness, math-system and actual physiological resilience, and then those might effect healthspan and longevity. (and so what?)

Some longevity things: So with histonation, acetylation and methylation, are there any pathway chemicals that come from nonproteinforming amino acid chemistry and availability as a rate limiting step? If there are, then supplementing that nonproteinforming amino acid could produce a rate change, and a new amount, of histonation, acetylation, decaetylation, or methylation. I previously thought of these histonation/acetylation/methylation things as gene driven and now think that rate limiting nonproteinformin amino acids (production of which could also be gene driven) could steer their actual longevity wellness healthspan youthful phenotype effects. Similarly, using the same thinking algorithm, as a longevity technology are there any things in the AMPK (metformin, CR) mTOR (rapamycin) that are rate determined from a nonproteinforming amino acid? Then more, less, or a different version of that nonproteinforming amino acid would be a longevity drug that amplifies metformin or rapamycin’s effect or even alone similarly amplifies the longevity effects of an endongenous chemical process; also a new version of the nonproteinogenic amino acid could have twice, half or an order of magnitude different AMPK, mTOR, or histone effects. Sort of like if a person said, “look GABA” and then another researcher said. “like phenibut cuold be an amino acid that takes pathway locations and actions” and if they were swapped there would be a bunch of organism changes.

So, an informed person could just look up longevity genes, then find any nonproteinogenic amino acids at their pathways, then suggest new, different nonproteinogenic amino acids, or synthetic chemicals that would change the amount of activity of those longevity genes at causing longevity with the purpose of increasing longevity;

I read people looked at the mitochondrial genome, mtDNA, to find longevity and energetics technology avenues; are there any essential or rate limiting nonproteinogenic amino acids active at functioning mitochondria? If there are then supplementing those, or otherwise modifying the amount that gets produced could have an effect on mitochondrial energy production, ATP availability, and possibly a calorie restriction, AMPK workalike that is without reference to the actual amount of food concerned.

putting drugs on either the brain side or body side of blood brain barrier: hydroxyproline is a zwitterion, and I read those stay out of the blood brain barrier, the thing is noopept, Pro-Gly concentrates at places like, but maybe different than, the frontal lobes and hippocampus, so even though it has a proline it passes the blood brain barrier.

entertainment value: like there could be a list of all the proton conductor-like things at the body, and all the proton-turned assemblies, and it would just be groovy to be aware of. Like, if you give a person lithium supplements does their proton mechanical work effects like go triple strength? Also, someone who knows could say something like, “well, last thing you heard these were really H3O+, so actually much larger than a hydrogen atom, but they still physically move around.

Longevity technology:
so, after a person makes alist of all the nonproteinogenic amino acids, and the amount they are different between a supercentenarian and a prepubescent child, thay could make a supplement that brings the supercentenarian to the prepubertal child’s nonproteinformingaminoacid amount; This might be extremely liposomal to get to the gi tract without digestion, so it might be a bunch like a a milkshake or a flavorless beauty topical emulsion. Another possibility is genetically engineering a probiotic to make sufficient GI tract absorbable nonproteinforming amino acids to cause amounts at supercentenarians to rise to those of prepubertal children.


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