cytomembrane fragments with a stable, typical to living structures of a molecular biological form of the kind of deleterious cyte terminating senolytics terminate, Then screen libraries of wild-type bacteria, fungi, plants, and even virus products to find out if they effect, modify, block, cause hypertransport at, or disintegrate these molecular biology structures.
Also, a novel thing, place a bunch of the actual molecules and proteins that are the unique biomolecular structures of the kinds of cytes senolytics terminate, at a culture medium, perhaps a (1000 times 1000) million multiwell plate, that contains a wide survey of bacteria, wild yeast, and variations on what humans think of as beneficial bacteria (probiotics); possibly use micropositioning to place a zone of molecular biology unique structures, a diffusion gap. and then a bacterial growth area: this causes material that diffuses across the zone to be measurable as to its quantitative effect on the unique molecular biological structures of the kind of cytes senolytics direct their effects at; When some of the million sample multiwell plates find bacteria, fungi, even viruses hosted by human tissue culture cytes products’ or other materials that cause plugging, blocking, hypertransport amplification, or disintegration of the unique molecular biological structures of the kind of cytes senolytics terminate, then organisms that produce new senolytics have been identified and can be quantified as longevity, wellness, healthspan, and youthful phenotype producing drugs. These wild type organisms can also be bred to have much higher amounts of senolytic chemicals. That is a new source of senolytic drugs.
As a technology, an immune response generating functions-like-a-senolytic yeast beverage or yogurt, plant, or plant pollen, bscteria, or even physiologically and attentionally nonperceptible dermal bacteria, similar to a probiotic, that is a senolytic from immunofunctioning, that is the immunosensitizing bacteria, plant, fungi or even virus causes greater longevity, wellness, healthspan, and youthfulness of phenotype like senolytics do. The humans, that is person’s or people’s immune response to optimally, the organisms or ok, but less nifty as it goes with actual human sustained production of concentrates, organism material concentrates, where both and either of these causes the immune system to be sensitized to glom and terminate the kind of cytes senolytics terminate.
So, perhaps: blenderized e coli membranes, combined with cytomembrane molecule transport channel plugs that preferentially populate deleterious chemokine and deletarious cytokine export channel (efflux) transport channels, also combined with some oil to make liposomes that make it through the GI tract;
So where do the at-wild, at 2019AD society, efflux blocker molecules come from? Organisms at a culture medium with chemical travel zone and an area of chemically changeable molecular biology structures to measure the modification efficacy of each of the organisms forms is described. As another source of efflux channel blocking molecules that are combinable with immunosensitizing decorations on the efflux blocking molecule, for immunoglomming and removal, which has a senolytic function effect.
It seems like it would be possible to screen a library of naturally occuring materials and molecules,proteins, peptides,andother things, as well as genetically engineered materials like new or enhanced proteins and peptides, to find out if there are any that plug the efflux channels that are effluxing deleterious biochemicals.
It might be that to a molecular biologist this is sort of easy, like “the transport channel is n angstroms wide and w angstroms tall. Anything hydrophobic/hydrophilic you make with an angle bend, a beta sheet or an alpha helix on it will block the efflux channel of that size and form. If you make a 20 amino acid peptide tail and put iton the plugging protein, you can use an amino acid that is absent any environemental or body-wide previous immune sytem antigen stimulation, or immune system activity. Immunocytes that react to the unique 20 mer peptide, after the “immune system alerting dose” are unlikely to react to any other physiological biochemical, minimizing immunological reactions drift, thus keepin nearer optimal human, immunofunction, human longevity, human wellness, and youthful phenotype form at the human.
The technology is that if just those cytes are immunoterminated which have a bunch of efflux channels where deleterious cytokines, chemokines, and matrix protein messer-uppers are effluxed, then that immunotermination functions like a senolytic:
Gene therapy, that transfects and terminates deleterious cytes with something like apoptosis, gene therapy that produces immunoequivalents to senolytic drugs, or gene therapy that actually produces proteins or peptides that are senolytic in their own right. Technology of senolytic longevity, wellness, healthspan, and phenotypic youthfulness of form are developing. At 2019 AD, at any deleterious cyte where a senolytic accumulates at but previously did not terminate as it would more optimally do, gene therapy could be a way to get the 30% that fisetin does not reach, the 50% that curcurmin does not reach, or the numerous kinds of cytotypes and tissues that any known senolytic might not reach the cytoplasm of (cartilidge, eye lenses, osteocytes, other nonvascularized tissues).
Curcurmin and fisetin are published senolytics; could curcurmin as well as fisetin molecules with an antibody alerting moeity or tail, attached with: an enzyme endogenous to the cytoplasm that divides the curcurmin or fisetin from the immune system alerting moeity, which then travels to the outer surface of the exterior cytomembrane, which alerts the immune system to terminate the cyte that the senolytic has already localized and concentrated at. That only works if fisetin, curcurmin, andother senolytics actually localize to deleterious cytes. If they just go to allcytes, but only terminate deleterious ones, then a different technology would be the thing to make. If senolytics do localize and concentrate at deleterious cytes then putting immunoactivators on them would cause them to be even more senolytic as the immunocytes seek them out.

wellness technology: somehow leukocytes, macrophages and WBCs notice they are more effective at being an active and beneficial immune system when they travel past the capillary epithelia to actual cytotypes that provide a utility definition to a tissue (chondrocytes, pneumocytes, cardiocytes, dermatocytes, beneficial only immune responses to neurons, glia, mesentary, hepatocytes) to have a curative beneficial effect; that is they make their way past the epithelia to reach pneumocytes to engulf pneumocytes that have viruses and cure pneumonia when they do that. So, is there a chemical peptide or protein that causes luekocyctes and other immunocytes to move past, or between, epithelial cytes twice as often, twice as fast, or even travel preferntially along tissue cytes and omit a travel path that is along epithelial lined passgaeways like capillaries? Those would be drugs that multiply the effectiveness of the immune system at interacting with and vanquishing infections. Kindof like the utility of antibiotics, it could be possible to terminate twice as many infected cytes orinvasive organismsevery 24 hours, rapidifying recovery from illness and improving wellbeing.
screenalibrary,
lookfor variants at a human population, find the genetics of passing epthelia or omitting travel at epithelial separation from the tissue cytes to be beneficially immunoterminated. Gene therapy could then produce muchhigher effectiveness immune systems at the people whoget the genetherapy who then have immune function that is twice as effective as passing, or passes twice as frequetly throughepithelia. Similarly my perceptionisthe leukocytes WBCs and other immunocytes have chemoreceptors. it is possible that at humans some human immune systems have twice the ability to sense, accurately a immunomeaningful chemical or molecule; These might be much more effective at sensing things at a distance when to pass an epithelial structure like a capillary to reach an actual tissue cyte to terminate the deleterious cytes and cause healing. One thing supporting the twice as effective idea is that at other body systems human capability differences between and amongst 2019 AD humans ranges over amounts much more than twice as effective, human vision, from 20-15 to 20-30, at immunoreactivity, children and adults have notably different immune learning libraries, much more than two times different, even persons of normal mental capability during 2019 AD could have brains that were twice or half as weighty. The technology is then, find an area of the immune system, particularly rapid, affordable, and effective at being changed, where the difference betweena human withthe most beneficial versionand a median activity humanis twice the effectiveness or greater. Then amongst that list of doubled or higher immune system capability, find the capabilities that respond withgreater ability most effectively to drugs, plants or other organisms, gene therapy, germline modification, lifestyle changes, and
Possibly things like biologically originated duration of immunity from an exposure could cause some people to be ill half as often (twice effectiveness) at areas, mostly previous to the 21st century, where disease organisms were persistent at the environment. So these persons would be able to omit becoming ill twice a as long or twice as effectively as others when re-exposed.
Adjuvants. I read about vaccine adjuvants. Are there any physiologically harmless adjuvants, possibly what were known during 2019 AD as GRAS food additives? Adjuvants similar to those that are a part of vaccines; these adjuvants when taken orally cause the entire volume of the body to be more effective at beneficially developing an immune response. So basically, if a person gets athlete’s foot, taking an oral adjuvant makes them twice as effective at developing an effective immune response to the fungi, so that makes them be cured twice as fast and be half as likely to have a recurrence. It is possible a bodywide adjuvant could reduce pneumonia, saving lives, although infection frequency could just be from organism variety; also, there is research on food, lifestyle, and cancer prevention. I have not heard of how taking adjuvant pills could make it so non detectable carcinogenesis is twice as immuno reacted to, thus the persons as a population, as measured at a population, get cancer as disease half as often.
Wikipedia mentions PAMPS, “Adjuvants accomplish this task by mimicking specific sets of evolutionarily conserved molecules, so called PAMPs, which include liposomes, lipopolysaccharide (LPS), molecular cages for antigen, components of bacterial cell walls, and endocytosed nucleic acids such as double-stranded RNA (dsRNA), single-stranded DNA (ssDNA), and unmethylated CpG dinucleotide-containing DNA.[4] Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction with the vaccine can greatly increase the innate immune response to the antigen by augmenting the activities of dendritic cells (DCs), lymphocytes, and macrophages by mimicking a natural infection.” things that look like cytostructures, a lot of different things have as adjuvants.”, screening large libraries of PAMPS could find better adjuvants and possibly those that if taken orally, possibly as parts of liposomes, provide beneficial systemic immune sytem enhancement.
It is possible to imagine liposomes, or artificial lipid bilayer bags, that have proteins on their surfaces causing engineerable changes in immune response, that is, being adjuvants;
Bag surface proteins could be kind of purposefully noncomplex, priming for a broad different similar group of proteins to recognize. Noting the lipid bilayer bag could be made out of different lipids it is possible lipid bags made out of really lengthy new omega 3s like C20 or C27 could be hyperdurable yet physiologically harmless or even measurably beneficial as omega-3s when they disintegrate. My perception is that some kinds of liposomes are ultraffordable to produce, sort of like: oil, water, ultrasonic transducer manufacturing.
They could screen a library of mlecules to find out if there are better adjuvants than “alum”, aluminum phosphate. Gallium is at the same row of the periodic table so they could try that. Also, noting the milligrams or possibly even micrograms of aluminum phosphate at an injection it is possible aluminum phosophate liposomes that make it past the GI tract could produce the same chemical concentration as an injected dose from oral consumption; it could have its flavor made palatable rather than tasting like alum because of the liposomes.
Also, they could find out if oral food: pickles, which contain alum, have an immunobeneficial, all-body adjuvant effect on laboratory mammals, and also do correlation studies on humans that eat pickles. It is possible there are other adjuvant foods, possibly some kind of recipe for liposomal transport of something immunoadjuvantish, so like a salad dressing, a nugget dipping sauce, a dilute milk drink, or a new kind of quantifiably physiologically beneficial margarine to make liposomes or lipid bilayer bags with and at.. There is a chance that oil coated fried potatos like french fries could have a liposome producing oil-water effect, or a purposeful coating; the technology to think of though is what is at the core of the liposomal bag; PAMPS; something like “vegemite”, dried yogurt powder enzyme product (basically a bunch of bacterial cytostructures and mambranes as a heap of legos), I read activated carbon, and I think zeolite like aluminum oxide, so possibly some naturally occuring zeolite like mineral, at liposomal bags. They could also make artificial zeolite that is, imaginably many times more effective than other forms of aluminum oxide, although it might not be.
If zeolites work as adjuvants, then a variation of the food thing sodium silico aluminate might be sort of like a ceramic material that could have a different zeolite like form that could be an adjuvant.
silica gel adjuvants: Other silica materials that might have adjuvant character, be placeable at liposomes, or could have an adjuvant like aluminum or gallium phosphate or ion exchange resins dissolved in them are silica gels, it is possible silica gels have different AMU amounts of silica networks, so perhaps they have light and medium ones, ones that adsorb strongly, others that adsorb weakly, also, silica gels can absorb liquids which I perceive might diffuse out again over hours, so if there is a liquid adjuvant it might go well with silica gel with liposomal bag around it; “The hydroxy (OH) groups on the surface of silica can be functionalized to afford specialty silica gels that exhibit unique stationary phase parameters. These so-called functionalized silica gels are also used in organic synthesis and purification as insoluble reagents and scavengers.” makes custom silica gels sound like they can be tuned to absorb or adsorb custom chemicals, there is even a chance that they could do some sort of simple localization, although it seems like to a silica gel, everything they are near would be epithelium.
Another, new to me approach to an oral immunization: If silica gels that are really eentsy are placed in liposomes then migrate through the small intestine to the circulatory sytem then perhaps they meet immunocytes like leukocytes or macrophages or WBCs or some other thing that react to them as a granular particle to be engulfed, I do not know how it works, but after being engulfed a silica gel particle might diffuse out something, even a liquid, that then causes a beneficial immune reaction.
Alginate jello blobs at liposomes might be an adjuvant, “adjuvants may provide physical protection to antigens which grants the antigen a prolonged delivery” That suggests the possibility that putting alginate jello in liposomes would cause alginate filled oil-water bags to travel around the circulatory system. These might pruprosefully leak alginate, causing some amount of antigens to get alginated-attached and then get gradually re-emitted; also ion exchange resins could be at liposomal bags and even glom and then gradually re-emit biological molecules of particular masses and surface charges.
Somewhat dubious, but it is my perception there are sometimes trace amounts of blood in stools. That suggests that an adjuvant, like a PAMP, aluminum or gallium phosphate at liposomes, that dissolves or migrates through membranes at the large intestine, or just contacts the sides of the large intestine, which, based on the blood at a stool concept, might have circulatory system distribution possibilities for something like the micrograms or milligrams of something like alum that could be a bodywide adjuvant.